Detalhe da pesquisa
1.
Disrupting autorepression circuitry generates "open-loop lethality" to yield escape-resistant antiviral agents.
Cell
; 185(12): 2086-2102.e22, 2022 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35561685
2.
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.
Cell
; 184(9): 2384-2393.e12, 2021 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33794143
3.
Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir.
Nature
; 613(7944): 558-564, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36351451
4.
Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir.
Nature
; 622(7982): 376-382, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37696289
5.
Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Nature
; 615(7953): 678-686, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922586
6.
Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7.
Nature
; 593(7857): 130-135, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33684923
7.
Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure.
Proc Natl Acad Sci U S A
; 121(15): e2316662121, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38557187
8.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612233
9.
Massively multiplexed nucleic acid detection with Cas13.
Nature
; 582(7811): 277-282, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32349121
10.
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.
Nature
; 585(7824): 273-276, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32516797
11.
Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges.
Drug Resist Updat
; 73: 101053, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38301487
12.
Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
Proc Natl Acad Sci U S A
; 119(30): e2203660119, 2022 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35858448
13.
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
Proc Natl Acad Sci U S A
; 119(36): e2206104119, 2022 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037386
14.
Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel.
Proc Natl Acad Sci U S A
; 119(42): e2210724119, 2022 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36191180
15.
New antivirals and drug resistance.
Annu Rev Biochem
; 78: 95-118, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19254207
16.
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients.
J Infect Dis
; 229(2): 413-421, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506264
17.
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Antimicrob Agents Chemother
; 68(4): e0137323, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38380945
18.
Microsecond dynamics of H10N7 influenza neuraminidase reveals the plasticity of loop regions and drug resistance due to the R292K mutation.
J Comput Chem
; 45(5): 247-263, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37787086
19.
Variable antiviral activity of islatravir against M184I/V mutant HIV-1 selected during antiretroviral therapy.
J Antimicrob Chemother
; 79(2): 370-374, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38153245
20.
Temporal trends and transmission dynamics of pre-treatment HIV-1 drug resistance within and between risk groups in Kenya, 1986-2020.
J Antimicrob Chemother
; 79(2): 287-296, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38091580